Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study

Abstract Background Autologous stem cell transplantation (auto‐SCT) is a widely used treatment option in multiple myeloma (MM) patients. The optimal graft cellular composition not known. Study design and methods Autograft was analyzed after freezing by flow cytometry 127 MM patients participating prospective multicenter study. impact of on hematologic recovery outcome auto‐SCT evaluated. Results A higher CD34 + content predicted faster platelet both the short long term. In with standard‐risk cytogenetics, count (>2.5 × 10 6 /kg) linked shorter progression‐free survival (PFS; 28 vs. 46 months, p = 0.04), but there no difference overall (OS) ( 0.53). multivariate model, CD133 CD38 − (>0.065 /kg, 0.009) NK 0.026), lenalidomide maintenance cytogenetics better PFS. contrast, 0.015) worse very low CD3 (≤20 0.001) infused high‐risk remained predictive OS. Conclusions may auto‐SCT. More studies are needed to define composition.